DNA Damage, Neurodegeneration, and Synaptic Plasticity
نویسندگان
چکیده
1Department of Cell Biology and Neuroscience, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy 2Instituto de Neurociencias, CSIC-UMH, Avenida Ramón y Cajal s/n, 03550 Sant Joan d’Alacant, Spain 3Institute of Applied Physiology, Ulm University, 89081 Ulm, Germany 4Institute of Anatomy and Medical Cell Biology, Heidelberg University, 69120 Heidelberg, Germany 5Klinikum Rechts der Isar, Department of Anesthesiology, Technische Universität München, Ismaninger Strasse 22, 81675 Munich, Germany
منابع مشابه
DNA polymerase β deficiency leads to neurodegeneration and exacerbates Alzheimer disease phenotypes
We explore the role of DNA damage processing in the progression of cognitive decline by creating a new mouse model. The new model is a cross of a common Alzheimer's disease (AD) mouse (3xTgAD), with a mouse that is heterozygous for the critical DNA base excision repair enzyme, DNA polymerase β. A reduction of this enzyme causes neurodegeneration and aggravates the AD features of the 3xTgAD mous...
متن کاملMild Traumatic Brain Injury of Tau.P301L Mice Results in an Impairment of Neural Plasticity
Background: Traumatic brain injury (TBI), even single-impact mild TBI (mTBI), is associated with increased risk of neuronal damage and neurodegeneration, leading to dementia, in particular Alzheimer’s disease (AD). The tell-tale histopathological defects of AD, deposits of amyloid and protein tau are observed following TBI. However, little is known about the mechanisms underlying the associatio...
متن کاملAspirin changes short term synaptic plasticity in CA1 area of the rat hippocampus
Introduction: The prostaglandin E2 (PGE2), a cyclooxygenase (COX) product, play critical roles in the synaptic plasticity. Therefore, long term use of COX inhibitors may impair the synaptic plasticity. Considering the wide clinical administration of aspirin and its unknown effects on information processing in the brain, the effect of aspirin and sodium salicylate on the short term synaptic p...
متن کاملThe Role of Adrenergic Receptors on Neural Excitability and Synaptic Plasticity: A Narrative Review
Adrenergic receptors have an important role in neural excitability and synaptic plasticity. Despite a lot of studies on these receptors, their exact role in brain disorders accompanied with hyperexcitability has not been determined. There are also controversies on their role in synaptic plasticity. In this review article, the important studies done in this regard have been reviewed to achieve a...
متن کاملCompartmental neurodegeneration and synaptic plasticity in the Wld(s) mutant mouse.
This review focuses on recent developments in our understanding of neurodegeneration at the mammalian neuromuscular junction. We provide evidence to support a hypothesis of compartmental neurodegeneration, whereby synaptic degeneration occurs by a separate, distinct mechanism from cell body and axonal degeneration. Studies of the spontaneous mutant Wld(s) mouse, in which Wallerian degeneration ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
دوره 2016 شماره
صفحات -
تاریخ انتشار 2016